JNTU B.PHARM I YEAR PHARMACEUTICAL ORGANIC CHEMISTRY QUESTION PAPER, JUNE 2010

JAWAHARLALNEHRUTECHNOLOGICALUNIVERSITY,HYDERABAD
B. Pharmacy I Year Regular Examinations, June 2010

PHARMACEUTICAL ORGANIC CHEMISTRY-I

Time : 3 Hours Max. Marks : 80
Answer any Five Questions
Each Question carries 15 Marks
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1. a) Explain tetrahedral and trigonal hybridization.

b) Explain the following terms
i) Bond length
ii) Bond angle.
iii) Dipole movement.
iv) Hydrogen bonding.

2. a) Define isomerism and list different types of isomerism with examples.

b) Explain the stabilities of cycloalkanes using bayer’s strain theory .
i) 2, 2, 4- trimethyl pentane
ii) Ethyl ethanoate

3. a) Explain Friedel-Crafts alkylation and Friedel-Crafts acylation reactions of
benzene.

b) Explain the electrophilic substitution reactions of naphthalene.

4. Define nucleophilic substitution reaction and explain reaction mechanism of SN1
and SN2 reaction.

5. a) Describe Zeisel method and give its significance.

b) Define rearrangement reaction and explain Fries rearrangement reaction.

6. a) Give an comprehensive account on oxidative reactions of carbonyl compounds.

b) Explain the following reaction with its mechanism
i) Clemmensen reduction
ii) Wolff- kishner reduction.

7. a) Explain Hell- Volhard- Zelinsky reaction.

b) Explain about Hofmann’s degradation of amides.

8. a) Explain about Hinsberg method of amine separation.

b) Explain the following reactions
i) Sandmeyer reaction
ii) Gattermann reaction
iii)Gabriel’s phthalamide synthesis.