NIPER-JEE                             GPAT                             PGECET                             GPAT 2011 DATES                             QUESTION PAPERS                             QUESTION PAPERS

Tuesday, December 14, 2010

NIPER-JEE



What is NIPER-JEE?
National Institute of Pharmaceutical Education and Research(NIPER)conducts National level entrance examination NIPER-JEE for admission into M.S.(Pharm);M.Tech.(Pharm);M.Pharm and M.B.A(Pharm).

NIPER INSTITUTES:
There are 7 NIPER institutes distributed throughout India.

NIPER Ahmedabad :Biotechnology,Natural products,Pharmaceutics.

NIPER Guwahati :Pharmacology & Toxicology,Pharmacy practice.

NIPER Hajipur :Biotechnology,Pharmacoinformatics,Pharmacy practice.

NIPERHyderabad:Medicinalchemistry,PharmaceuticalAnalysis,PharmacologY&Toxicology

NIPER Kolkata :Medicinal chemistry,Natural products,Pharmacoinformatics.

NIPER RaeBarelli:Medicinal chemistry,Pharmaceutics.

NIPER S.A.S Nagar:Biotechnology, Medicinal Chemistry, Natural Products, Pharmaceutical Analysis, Pharmaceutical Management, Pharmaceutical Technology (Biotechnology), Pharmaceutical Technology (Bulk Drugs), Pharmaceutical Technology (Formulations), Pharmaceutics, Pharmacoinformatics, Pharmacology & Toxicology, Pharmacy Practice, Regulatory Toxicology, Traditional Medicine.

Who can be Eligible ?

ELIGIBILITY : Well coming to eligibility,

Eligibility- (A) M.S. (Pharm.); M.Pharm. ; M.Tech. (Pharm.)

Medicinal Chemistry

M.S. (Pharm.)

B.Pharm./M.Sc.(Organic Chemistry)

Natural Products

M.S. (Pharm.)

B.Pharm./M.Sc.(Organic Chemistry)

Traditional Medicines

M.S. (Pharm.)

B.Pharm./B.A.M.S./M.Sc.(Botany)

Pharmaceutical Analysis

M.S. (Pharm.)

B.Pharm./M.Sc.(Organic/ Analytical Chemistry)

Pharmacology & Toxicology

M.S. (Pharm.)

B.Pharm./B.V.Sc./M.B.B.S.

Regulatory Toxicology

M.S. (Pharm.)

B.Pharm./B.V.Sc./M.Sc.(Pharmacology/Toxicology/Life Sciences/Biochemistry/Medical Biotechnology/ Zoology)/M.B.B.S.

Pharmaceutics

M.S.(Pharm.)

B. Pharm.

Biotechnology

M.S.(Pharm.)

B.Pharm./M.Sc.(Biological Sciences)

Pharmaceutical Technology (Formulations)

M.Pharm.

B.Pharm.

Pharmaceutical Technology (Bulk Drugs)


M.Tech. (Pharm.)

B.Pharm./M.Sc.(Organic Chemistry)/B.Tech. (Chemical Engg. or equivalent)

Pharmaceutical Technology (Biotechnology)

M.Tech. (Pharm.)

B.Pharm./M.Sc.(Life Sciences)

Pharmacy Practice

M.Pharm.

B. Pharm.

Pharmacoinformatics

M.S. (Pharm.)

B.Pharm./M.Sc.(Organic Chemistry/Pharmaceutical Chemistry)/M.Sc./B.Tech. (Bioinformatics)/M.Sc. (Biochemistry/Biotechnology/Molecular Biology/Microbiology)

Eligibility - (B) M.B.A. (Pharm.)

Discipline

Programme

Pharmaceutical Management

M.B.A.(Pharm.)

B.Pharm./B.Tech.(Chemical Engg. or equivalent)/ M.Sc. (Chemical / Life Sciences)

* Candidates should have a minimum CGPA(Cumulative grade point Average)of 6.75 or 60% marks.
For General categeory, CGPA 6.25 or 55% marks.
For SC/ST, CGPA 5.75 or 50% marks.
For physically Handicapped candidates (PHC) On a 10 point scale in the qualifying exam and also have a valid GPAT/GATE/NET qualification.
For more detailed info. CLICK HERE

* Candidates appearing in the Final year of Qualifying exam are also eligible to apply for NIPER-JEE. However they must submit the final result at the time of counselling.

HOW TO APPLY ?
Application form can be obtained in person or by post from the Office of Organising Chairperson,NIPER-JEE on submission of non-refundable Bank Demand Draft of Rs.1000/-(Rs.500/- for SC/ST).
* Completely filled applications should be sent to the address mentioned in the information brochure before the last date.
NOTE: * The completed application must have attested copy of valid GPAT/GATE/NET score card attached to it.

SYLLABUS :

Medicinal chemistry and Bulk Drugs (Pharmaceutical Technology)
IUPAC nomenclature, R and S nomenclature, E and Z isomerism, atropiisomerism, Conformations
Hybridization, aromaticity, Huckel’s rule reaction mechanisms- Electrophilic, Nucleophilic, SN1, SN2, SNi, Elimination E1 E2 etc.
Ester hydrolysis, Aac1 Aac2……all eight mechanisms (Jerry march) Markovnikoves rule, Bredts rule, Stereoselectivity, stereospecificity, regioselectivity, chemoselectivity, chirality, stereochemistry, conformations, rearrangements, acids and bases.
Imine-enamine Tautomerism, keto-enol tautomerism, pericyclic reactions, racemic mixture, resolution methods.
Amino acids proteins, various methods for amino acid detection, Ninhydrin test, peptide sequencing, structures of amino acids, essential and nonessential amino acids,
Introduction to thermal methods of analysis like, TGA, DSC, DTA etc.
Carbohydrates classification, osazone test, mutarotation, etc,
Various Heterocycles, Heterocycle synthesis, reactions.
Introduction to Redox reactions.
Spectroscopy: (basics specially): Very very IMP topic. NMR, and C-NMR ranges from Morrison & Boyd or Pavia Mass -Basic concepts about various peaks M+1, molecular ion, base peak etc. (Silverstein) IR - Frequencies of various groups specially carbonyls. UV
Chromatography: Details of every chromatographic method.
Reaction kinetics, first second third and pseudo first order reactions, radio labeling for determination of mechanism.
Common condensation reactions like Aldol, Claisen Perkin, Dickmann, Darzen etc.
Other reactions like Cannizarro’s reaction, Prins reaction, especially reactions of carbonyl compounds.
References:
1. Jerry March
2. Morrison and Boyd (ESPECIALLY Peptide and Carbohydrate chemistry)
3. I. L. Finar Vol-I and Vol-II (Heterocyclic chemistry and organic synthesis)
4. Eliel

Natural Products :
In natural products more stress should be given on phytochemistry part rather than biological aspects.
Methods of extraction, isolation and characterization of natural products. Various separation techniques used for isolation of natural products.
Biosynthetic pathways.
Primary metabolites, their examples.
Secondary metabolites, various classes of secondary metabolites (e.g. Alkaloids, glycosides, tannins, lignans, saponins, lipids, flavonoids, coumarins, anthocyanidines etc.). Here most imp. Part is chemistry of these classes.
Important therapeutic classes: antidiabetics, hepatoprotectives, immmunomodulators, neutraceuticals, natural products for gynecological disorders, anti-cancer, anti-viral (mainly anti-HIV), adaptogens etc.
Dietary antioxidants, Marine natural products, Plant growth regulators.
Spectroscopy: Basic concepts of UV, NMR, IR and Mass spectroscopy. Give more stress on IR and NMR.
Stereochemistry: Basic concepts.
Fischer, sawhorse and newmon projection formulaes.
Biological sources of important classes of natural products. (Selected ones only)
Standardization of natural products.
What is difference between natural products and pharmacognosy?
References:
1. For various therapeutic classes: Trease and Evans
2. For spectroscopy: Silverstein, Pavia, Kemp.
3. For stereochemistry: I.L. Finar vol-II

Pharmacology and toxicology:
Pharmacokinetics, pharmacodynamics, pharmacological effect, desired, undesired, toxic, adverse effects.
Bioavailability, bioequivalence, various factors of ADME. (From Bramhankar)
Drug metabolism: various pathways and other details.
Drug interactions, agonist, antagonist, partial agonist, protein binding, drug distribution, distribution volume, excretion pathways etc.
Pharmacological screening: general principles, various screening models, screening methodologies (in vitro and in vivo tests).
Mechanism of drug action, drug-receptor interaction.
Various adrenergic, cholinergic and other receptors
Detailed study of CNS pharmacology
Study of basis of threshold areas of work in NIPER in pharmacology dept. mentioned in brochure.
Diseases: study of the pharmacology of the diseases and drugs used with mode of action especially of diabetes, malaria, leishmaniasis, TB, hypertension, myocardial ischemia, inflammation, and immunomodualtion.
Chemotherapy and pathophysiology- knowledge of antibiotics, their mode of action and the microorganisms responsible for various common diseases.
Bioassay methods, various requirements. Brief knowledge of the statistical tests.
References:
1. Rang and Dale (ALL CHEMOTHERAPY CLASSES OF DRUGS. IF YOU READ THE WHOLE BOOK, then nothing else is needed)
2. F. S. K. Barar
3. Wilson and Griswold (for Mechanism)
4. Kasture (for Bioassay and Screening)

Pharmaceutics and formulation (Pharmaceuticl Technology)
Drug delivery systems (DDS): NDDS models, osmotic pumps, various release patterns eg. Controlled release, delayed release. Sustained release etc., order of release. Oral controlled DDS, factors affecting controlled release.
Carriers in DDS: polymers and their classification, types, carbohydrates, surfactants, proteins, lipids, prodrugs etc.
Transdermal drug delivery systems (TDDS): principles, absorption enhancers, evaluation of TDDS.
Parenterals: requirements, advantages, disadvantages, release pattern, route of drug delivery.
Drug targeting: microspheres, nano particles, liposomes, monoclonal antibodies, etc.
Preformulation detailed.
Complexation, solubilization, polymerization, viscosity measurements.
Dosage form development- stages, implications of dosage form.
Additives of formulation, types, examples, advantages, disadvantages, drug excipient interaction, incompatibility, various types of incompatibilities.
Dosage forms: solid (tablets, capsules, pills etc), liquid (emulsion, suspension etc), sterile (injectables), aerosols. Principles, advantages, disadvantages and problems.
Coating - in detail.
Packaging: materials, labeling etc. Types of containers (e.g. Tamper-proof containers)
In process controls, Product specification, documentation.
Compartmental modeling. (From Bramhankar)
Bioavailability, bioequivalence studies. Methods of improvement of oral bioavailability.
Evaluation of formulation, principles and methods of release control in oral formulations.
References:
1. Lachmann (ALL new and old techniques in Pharmaceutical Industry)
2. Alfred Martin (ALL physical chemistry BASICS)
3. Remington’s Pharmaceutical Sciences
4. Notes of Gudsurkar Sir (Most important)
5. Banker series.
6. other: Bramhankar, , Liberman Series

Pharmaceutical analysis:
Stability testing of pharmaceuticals, various stability tests, kinetic studies, shelf life determination, thermal stability, formulation stability.
Various analytical techniques
Tests: physical and chemical tests, limit tests, microbiological tests, biological tests, disintegration and dissolution tests.
Spectroscopic methods; UV, NMR, IR, MS, FT-IR, FT-NMR, ATR (Attenuated Total Reflectance), FT-Raman- basics and applications.
Thermal techniques: DSC, DTA, TGA, etc.
Particle sizing: law of diffraction.
Electrophoresis: capillary electrophoresis.
Chromatography- detailed.
QA and QC: GLP, TQM, ISO system.
Preformulation, cyclodextrin inclusion compounds
Solubility: pH, pka, surfactant HLB values, Rheology.
Crystallinity, polymorphism, solvates and hydrates, crystal habits, porosity, surface area flow properties.
Dosage forms, Stages of dosage form development
Osmolality, osmolarity, osmotic pressure, conductivity, Preservatives, Media for bioassay.
References:
1. Willard
2. Silverstein (Mass Spectroscopy)
3. William Kemp (NMR)
4. Pavia (for spectroscopy)
5. Others like Alfred Martin, Chatwal (UV), Garry Christen (Chemical Methods)

Biotechnology:Pharmaceutical technology biotechnology
Genetic Engg: Gene expression, mutation, replication, transcription, translation, recombination, bacteriophages.
Cloning: methods, isolation of nucleic acids, enzymes in cloning (restriction endonucleases, DNA ligase, DNA gyrase, polymerases etc...), functions of these enzymes, Pallindromes.
Fermentation: fermenters, fermentation process, its regulation, conditions, bioprocessors, various enzymes in fermentation technology. Fermentation of Antibiotics, vitamins, amino acids, hydroxy acids such as lactic acid etc. Chemical engg. aspects realated to fermentation
Gene therapy: methods and applications.
Monoclonal antibodies, insulin, interferons, enkephalins, angiotensin analogues and other peptides.
References:
1. Vyas and Dixit
2. IP Appendices

Practice of Pharmacy:
The best part for the preparation for this best reference for this would be Remington’s Pharmaceutical Sciences. This branch is quite new here, so till dates students of branch used to do case study of prescriptions in Fortis hospital, PGI Chandigarh and govt. college chd... This is much like pharmacology and drug-drug interactions and different interactions are emphasized. Diabetes, heart diseases are main area of study……….

Pharmacoinformatics:
Terminologies related with new emerging informatics e.g. proteomics, genomics, QSAR (2D, 3D, regression, correlation).
References:
Foye, Williams and Lemke, Medicinal chemistry, 5th/6th edition, chapter 1-6. (Computational drug design and molecular modeling).

Others:
Statistics, general mathematics and aptitude questions. Use MBA entrance test books like CET or CAT in MBA. Additionally some general awareness questions.
NIPER’s thrust areas are:
Microbial and viral diseases: Yeast, and fungi.
Parasitic and tropical diseases: Malaria, Leishmaniasis, amoebiasis, etc.
Metabolic Disorders: Diabetes
Strokes
Peptide and carbohydrate chemistry.
Genomics and proteomics: yeast and fungi
Hormonal disorders: TRH related diseases.

EXAM PATTERN:
A Common written test for all disciplines of the masters programme will be of 2 Hours containing 200 Multiple Choice Questions. There will be Negative marking also. For each Wrong answer 0.25 mark will be deducted ( i.e., 25% Negative marking or 1/4th Negative marking). For MBA a part from the written test there will be interview and group discussion also.

EXAM CENTRES :
A common written test for all disciplines of all Masters Programme will be conducted in Ahmedabad, Bangalore, Baroda, Chennai, Delhi, Guwahati, Hyderabad, Jaipur, Kolkata, Lucknow, Madurai, Mumbai, Nagpur, Nagpur, Patna, Pune, Trivandrum, Varanasi.

COUNSELLING CENTRE : Counselling is done at NIPER S.A.S Nagar (Mohali), Punjab.

CONTACT : National Institute of Pharmaceutical Education and Research(NIPER),
Sector 67,
Phase x,
S.A.S Nagar,
Punjab.
India - 160062.
Website : www.niper.gov.in


ALL THE BEST.

2 comments:

  1. for any query related to NIPER test,
    please visit www.euerkapharmakon.com or
    call at Phone : +91 7567982272 or
    send Email at: info@eurekapharmakon.com

    ReplyDelete
  2. Wow, this is the best site I’ve ever read. Thank you for sharing this.mba college in punjab

    ReplyDelete